The Research

Lion’s Mane (Mushroom) (Nootropic) (Adaptogen) 

Lion’s Mane is a mushroom with neuroprotective and nootropic effects. Lion’s Mane can improve memory and reasoning.*

Properties: Increases NGF levels in the brain – enhanced neuronal growth, regeneration and synaptic plasticity [1] Improves myelination – enhanced neuronal communication and nerve regeneration [2] Increases long-term synaptic potentiation – improved memory [3,4] Decreases glutamatergic transmission – decreased neuronal excitability and excitotoxicity [3,4] Protects neurons from endoplasmic reticulum stress [3,4] Anxiolytic [5] Anti-inflammatory effects [6]*

REFERENCES

[1] Lai PL, et al (2013). Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms, 15(6):539-54. doi: 10.1615/IntJMedMushr.v15.i6.30

[2] Kolotushkina EV, et al (2003). The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh, 49(1):38-45. PMID: 12675022

[3] Phan CW, et al (2015). Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol, 35(3):355-68. doi: 10.3109/07388551.2014.887649

[4] Sabaratnam V, et al (2013). Neuronal health – can culinary and medicinal mushrooms help? J Tradit Complement Med, 3(1):62-8. doi: 10.4103/2225-4110.106549

[5] Nagano M, et al (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res, 31(4):231-7. doi: 10.2220/biomedres.31.231

[6] Geng Y, et al (2014). Anti-inflammatory activity of mycelial extracts from medicinal mushrooms. Int J Med Mushrooms, 16(4):319-25. doi: 10.1615/IntJMedMushrooms.v16.i4.20

 

Cordyceps (Mushroom) (Nootropic) (Adaptogen) 

Cordyceps mushroom is a nootropic compound also known as; Cordyceps Sinensis, Cordyceps Militaris, Caterpillar Fungus, Cetepiller Mushroom, Summer grass-winter worm, Totsu kasu, Yarchakunbu, Aweto

Properties: Significant neuroprotective properties (reduction of neuronal cell death) in the hippocampal region* [1], where dementia is found, improved learning and reduced memory impairment, improved spatial memory* [1], Adaptogen, antiasthmatic, antileukemic, antiooxident, hepatoprotective, hypocholesterermic, immune system amphoteric, nephroprotective, and sedative.* [2]

REFERENCES

[1] Neuroprotective and therapeutic effect of Cordyceps militaris on ischemia-induced neuronal death and cognitive impairments. https://www.sciencedirect.com/science/article/pii/S1319562X1830192X

[2] Adaptogens - Herbs for Strength, Stamina, and Stress Relief - David Wilson and Steven Maimes

 

Reishi (Mushroom) (Nootropic) 

Evidence on reishi mushroom show it is most powerful as a immune booster* [1] and has applications fighting tumors and cancers in animal and human studies* [1]. The reishi mushroom is also neuroprotective and can even support the growth of neurogenesis through chemicals like brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)* [1].

Properties: reduction of anxiety[1], reduced fatigue* [1], improved neurogenesis* [1], increase delta and other wave activity in the brain* [1], helps enhance the quantity of brain chemicals NGF and BDNF* [1], immune system support* [2], heart health [2], blood sugar control* [2], antioxidant* [2]

REFERENCES

[1] https://www.nootropedia.com/reishi/

[2] www.medicalnewstoday.com/articles/318527

 

Bacopa (Nootropic) 

Studies indicate that Bacopa monnieri has neuroprotective, nootropic and adaptogenic effects. Research shows that it can improve memory formation and recall.*

Properties: Bacosides are the active ingredients in Bacopa monnieri [1] inhibits acetylcholinesterase, activates choline acetyltransferase* – increased levels of acetylcholine* [1], Increases neurite branching and proliferation – improves synaptic communication and memory* [1], Modulates the dopaminergic and serotonergic systems – mood enhancer* [3], Modulates the levels of superoxide dismutase (SOD) and oxidative damage from metals in the brain – protective against neurodegeneration* [4], Anxiolytic and analgesic effects* [5,6], Reduce the levels of the stress marker HSP70 in the brain – adaptogenic effect* [7]

REFERENCES

[1] Aguiar S, Borowski T (2013). Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation Res, 16(4):313-26. doi: 10.1089/rej.2013.1431

[2] Sivaramakrishna, C, et al (2005). Triterpenoid glycosides from Bacopa monnieri. Phytochemistry, 66: 2719–2728. doi: 10.1016/j.phytochem.2005.09.016

[3] Rauf K, et al (2012). Effect of acute and sub-chronic use of Bacopa monnieri on dopamine and serotonin turnover in mice whole brain. AJPP. 2012;6:2767–2774. doi: 10.5897/AJPP12.244

[4] Chowdhuri DK, et al (2002). Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res, 16(7):639-45. doi: 10.1002/ptr.1023

[5] Chatterjee M, et al (2010). Comparative evaluation of Bacopa monniera and Panax quniquefolium in experimental anxiety and depressive models in mice. Indian J Exp Biol, 48(3):306-13. PMID: 21046986

[6] Bhaskar M, Jagtap AG (2011). Exploring the possible mechanisms of action behind the antinociceptive activity of Bacopa monniera. Int J Ayurveda Res, 2(1):2-7. doi: 10.4103/0974-7788.83173

[7] Anbarasi K, et al (2006). Cigarette smoking induces heat shock protein 70 kDa expression and apoptosis in rat brain: Modulation by bacoside A. Neuroscience, 138(4):1127-35. doi: 10.1016/j.neuroscience.2005.11.029

 

Ashwagandha (Adpatogen)

Properties: Properties: anti-inflammatory, antioxidant [d] immune amphoteric [g], antispasmodic, mild astringent [h], antitumor, nervine* [i]. [1] 

[1] Adaptogens - Herbs for Strength, Stamina, and Stress Relief - David Wilson and Steven Maimes

 

Moringa (Adaptogen) 

Properties: Blood sugar regulation*, immune system function*, antibacterial*, antiviral*, anti-fungal*, and anti-parasitic*, anti-inflammatory*, anti-oxidant* [d], contains vitamins, carotenoids, tocopherols [f], and flavonoids can help to promote skin health. [1] 

REFERENCES

[1] https://nihrecord.nih.gov/past-issues

https://www.tandfonline.com/doi/abs/10.3109/09637489309017439

https://link.springer.com/article/10.1007%2Fs13197-012-0859-9

https://www.ncbi.nlm.nih.gov/pubmed/27013794

https://www.sciencedirect.com/science/article/pii/S2213453016300362

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583891/

 

Shatavari (Adaptogen)

Properties: antibacterial, antispasmodic, aphrodisiac immune response, lung response, galactagogue and gastroprotective, anti-inflammatory steroidal glycosides [b] as well as immune stimulating polysaccharides* [a]. [1] 

[1] Adaptogens - Herbs for Strength, Stamina, and Stress Relief - David Wilson and Steven Maimes

 

Rholdiola rosea (Nootropic) (Adaptogen) 

Rhodiola rosea is a flowering plant with nootropic and adaptogenic effects. Its biologically active compounds can improve memory and focus.*

Properties: Rosavins and salidrosides are its main biologically active compounds* [1] Inhibits monoamine oxidase* [2] Increases the levels of dopamine, noradrenalin, adrenalin, serotonin, and melatonin* [2] Regulates the opioid β-endorphin – improves mood* [3] Decreases fatigue, improves motivation and concentration* [3] Promotes longevity – neuroprotective against toxins and oxidative stress; increases the production of antioxidant enzymes* [4] Modulates neuropeptide Y activity, increasing HSP72 levels – anti-stress effects* [5] Enhances neurogenesis and neuronal regeneration – memory enhancement* [6,7]

REFERENCES

[1] Panossian A, et al (2010). Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine, 17(7):481-93. doi: 10.1016/j.phymed.2010.02.002

[2] van Diermen D, et al (2009). Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol, 122(2):397-401. doi: 10.1016/j.jep.2009.01.007

[3] Kelly GS (2001). Rhodiola rosea: a possible plant adaptogen. Altern Med Rev, 6(3):293-302. PMID: 11410073

[4] Qu ZQ, et al (2009). Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: implication of anti-oxidative and neuroprotective effects. Biomed Environ Sci, 22(4):318-26. doi: 10.1016/S0895-3988(09)60062-3

[5] Panossian A, et al (2012). Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells. Front Neurosci, 6:6. doi: 10.3389/fnins.2012.00006

[6] Qu ZQ, et al (2012). Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat. PLoS One, 7(1):e29641. doi: 10.1371/journal.pone.0029641

[7] Sheng QS, et al (2013). Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. Neuroreport, 24(5):217-23. doi: 10.1097/WNR.0b013e32835eb867

 

Amalaki (Amla Fruit) (Adaptogen) 

Properties: anti-inflammatory, antioxidant *[d], antiviral, lowers cholesterol. Amla is rich in antioxidants polyphenols* [c], and contains significant amounts of vitamin C as well as flavonols* [e]. [1] 

[1] Adaptogens - Herbs for Strength, Stamina, and Stress Relief - David Wilson and Steven Maimes

 

Chaga (Mushroom) (Nootropic) 

The chaga mushroom grows on birch trees throughout the northern hemisphere. It resembles a dark clump of dirt more than a mushroom, but is distinguished from other growths by its orange tissue

Properties: Chaga can support other markers of immune health, such as reducing DNA fragmentation and damage by 40%* [1], anti-cancer agent* [1] aids in general health and immune strength* [1] can decrease tumor cell growth while showing low toxicity or harmful effects in normal cells* [1] can inhibit oxidative DNA damage by over 40%* [1] Slowi the aging process* [2], lower cholesterol* [2], lower blood pressure* [2], support the immune system* [2], fight inflammation* [2], lower blood sugar* [2].

REFERENCES

[1] https://www.nootropedia.com/chaga/

[2] https://www.medicalnewstoday.com/articles/318527